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In this way lithium influence the glycogen synthase kinase-3 (Gsk3), and/or Akt (protein kinase B) signaling mechanisms (Williams and Harwood, 2000, Baldessarini and Tondo, 2000) to affect several neurotropic factors (Gould et al., 2004, Wada, 2009) such as the cytoskeletal framework, metabolic mechanisms, and gene expression control (Chen et al., 2010, Beaulieu et al., 2009)