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Just as GLP-1 in the body naturally does, GLP-1 medications work by: Stimulating insulin secretion, which allows cells to take up sugar Inhibiting the release of glucagon , which helps lower blood sugar levels Slowing stomach emptying, which can help prevent a post-meal sugar spike , as sugar from food is released more slowly into the bloodstream Increase how full you feel after eating Along with blood sugar management, these medications are also beneficial for weight management and reducing the risk of heart and kidney problems